Antibody facilitation of multiple sclerosis-like lesions in a nonhuman primate. Genain C, Nguyen M, Letvin N, Pearl R, Davis R, Adelman M et al. Augmentation of demyelination in rat acute allergic encephalomyelitis by circulating mouse monoclonal antibodies directed against a myelin/oligodendrocyte glycoprotein. Linington C, Bradl M, Lassmann H, Brunner C, Vass K. A monoclonal antibody against a myelin oligodendrocyte glycoprotein induces relapses and demyelination in central nervous system autoimmune disease. Schluesener H, Sobel R, Linington C, Weiner H. Type 1 diabetes genes and pathways shared by humans and NOD mice. Wicker LS, Clark J, Fraser HI, Garner VE, Gonzalez-Munoz A, Healy B et al. Positional identification of Ncf1 as a gene that regulates arthritis severity in rats. Olofsson P, Holmberg J, Tordsson J, Lu S, Akerstrom B, Holmdahl R. MHC2TA is associated with differential MHC molecule expression and susceptibility to rheumatoid arthritis, multiple sclerosis and myocardial infarction. Swanberg M, Lidman O, Padyukov L, Eriksson P, Akesson E, Jagodic M et al. A role for VAV1 in experimental autoimmune encephalomyelitis and multiple sclerosis. Jagodic M, Colacios C, Nohra R, Dejean AS, Beyeen AD, Khademi M et al. White matter disease: roles of anti-MOG antibodies in demyelinating diseases. Identification of a pathogenic antibody response to native myelin oligodendrocyte glycoprotein in multiple sclerosis. Zhou D, Srivastava R, Nessler S, Grummel V, Sommer N, Bruck W et al. Antibodies against the myelin oligodendrocyte glycoprotein and the myelin basic protein in multiple sclerosis and other neurological diseases: a comparative study.
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Matching of oligoclonal immunoglobulin transcriptomes and proteomes of cerebrospinal fluid in multiple sclerosis. Obermeier B, Mentele R, Malotka J, Kellermann J, Kumpfel T, Wekerle H et al. Taken together, our data demonstrated complex regulation of the antibody response during EAE and that skewing the antibody response toward Th2 contributed to protection from EAE. We confirmed that Amig3 regulates anti-MOG antibody levels in MOG-EAE, and further showed that immune reactions during initiation of EAE were skewed toward increased numbers of B cells in the EAE-protected APLEC strain, together with higher anti-MOG IgG1 and lower IgG2b levels. We fine-mapped the region to 539 kilobases (kb) consisting of a complex of seven C-type lectin receptor genes ( Dcir4, Dcir3, Dcir2, Dcir1, Dcar1, Mcl and Mincle) that was captured in the APLEC congenic strain. We show polygenic regulation of anti-MOG antibodies in two backcross populations, including a major genetic determinant for antibody expression on chromosome 4, Amig3. We aimed to determine the genetic regulation of anti-MOG antibodies and their involvement in disease, by using MOG-induced experimental autoimmune encephalomyelitis (EAE) in rat, an animal model that closely mimics human MS. There is evidence supporting a role of myelin oligodendrocyte glycoprotein (MOG) humoral immunity in MS. All rights reserved.Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system that is genetically complex. In this review, we examine the history of the MOG antibody and its relevance to demyelinating disease, as well as compare the clinical, radiographic and serological profiles of patients with MOG antibody with patients with AQP4 antibody.Ĭopyright © 2018 Elsevier B.V. MOG antibody disease has thus recently emerged as a distinct entity carved out of the patient population diagnosed with NMOSD. In recent studies around the world where MOG testing is available, up to 42% of NMOSD patients who test seronegative for the AQP4 antibody test positive for MOG antibodies. In addition, acute disseminated encephalomyelitis (ADEM) is a well-recognized phenotype of MOG antibody disease in children. Clinically, the disease resembles neuromyelitis optica spectrum disorders in the predilection for relapses of optic neuritis and transverse myelitis. MOG is a glycoprotein expressed on the outer membrane of myelin and solely found within the central nervous system, including in the brain, optic nerves and spinal cord. MOG antibody disease is an autoimmune disease of the central nervous system associated with a serological antibody against MOG, myelin oligodendrocyte glycoprotein.
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